Alpha-Fetoprotein Tumor Marker (AFP)

AFP concentrations are increased in patients with liver cancer, hepatitis, and liver cirrhosis. Increased levels in severe hepatitis indicate liver cell regeneration. Thus, the absence of AFP in patients with fulminant hepatitis is considered a poor prognostic sign.

AFP concentrations decline to normal levels with effective therapy. Persistently elevated levels suggest residual disease; rising levels suggest disease progression or recurrence.

Clinical Use: Distinguishs between seminomatous and non-seminomatous testicular germ cell cancer. Monitors therapy and detect recurrence in individuals with non-seminomatous testicular germ cell cancer. Determines prognosis in individuals with fulminant hepatitis. Monitors therapy in individuals with hepatocellular carcinoma and monitors hepatitis B carriers for evidence of liver cancer